MITO-MAP
Mitochondria
Mapping Altitude Physiology
MITO-MAP
Mitochondria
Mapping Altitude Physiology
1. Villa Guillén M, Quispe Copa WM, Villanueva García D, Arias-Reyes C, Soliz J. High-Altitude Hypoxia and Neonatal Outcomes: Sex-Dependent Predictors of Mortality and ROP. Resp Phys & Neorobiol. Submitted
2. Ovalle Orejarena O, Hernandez Ochoa D, Silva F, Molano Franco D, Romero Díaz H, Martinez Del Valle A, Fernandez VM, Provencher S, Rojas T, Iturri P, Arias-Reyes C, Soliz J. Circulating Erythropoietin and Sex-Dimorphic Plasma Proteomic Signatures in Preterm Infants with Apnea of Prematurity. Reddy to submit.
3. Vallejo A*, Sanchez L*, Aliaga-Raduan F, Iturri P, Kinkead R, Bairam A, Schneider Gasser EM, and Soliz J. (2025). Early-life Stress. Reprograms Redox and Mitochondrial Networks Governing Respiratory Control in Adult Mice. Redox Biology. Revision Requested.
4. Bolduc C*, Castelo Rueda MP*, Picón ML*, Gentile G, Vicoria Soto Linan V, Zanon A, Laouafa S, Lang M, Lavdas AA, Gilmozzi V, Coulombe V, Gora C, Peralta MR, Rioux V, Honisch C, Pramstaller PP, Paolo Ruzza P, Elena Ziviani E, Andrew A. Hicks, Martin Parent, Soliz J, Joseph V, Pichler I*, Levesque M*. (2025). Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction. Brain. Revision Requested.
5. Maldonado-Coronel F, Castillo-Caicedo C, Viruez-Soto JA, Huanca-Payehuanca R, Tinoco-Solórzano A, Molano-Franco D, Arias-Reyes C, Soliz J. Altitude-Specific Neurocritical Care: A Case Study in the Management of Traumatic Brain Injury. Medical Reports. In press.
6. Sephton C, Pelaez MML, Desmeules A, Soliz J, Kennedy J, Troakes C, Vance C, Durham H, Dutchak P. (2025). Targeting Lipid Droplets in ALS-FUS Ameliorates Lipotoxicity in Neurons and Astrocytes.Brain. In Press.
7. Demarest M, Aliaga-Raduan F, Arias-Reyes C, Gonzales M, Schneider Gasser EM, Soliz J, Joseph V. High altitude induces a shift from complex I to complex II in the brain mitochondria of newborn and adult mice. J Exp Biol. 2025 Aug 15;228(16):jeb250422.
8. Molano-Franco D, Masclans Enviz JR, Viruez-Soto A, Gomez M, Rojas H, Beltran E, Nieto V, AliagaRaduan F, Iturri P, Arias-Reyes C, Soliz J. (2025). Inflammation severity, rather than respiratory failure is strongly associated with mortality of ARDS patients in high-altitude ICUs. Frontiers in Physiology. 15(1520650): 1-12.
9. Arias Fernández DA, Romero Diaz HA, Figueroa Garnica AD, Iturri Soliz P, Arias-Reyes C, Schneider Gasser EM, Soliz J. (2025). Low and sustained doses of erythropoietin prevent preterm infants from intraventricular hemorrhage. Respir Physiol Neurobiol. 331: 1-8.Neurobiol.
10. Rojas-Ruiz A, Boucher M, Henry C, Gélinas L, Packwood R, Graham P, Soliz J, Bossé Y. (2025). Methacholine hyperresponsiveness in mice with house dust mite-induced lung inflammation is not associated with excessive airway constriction ex vivo. Exp Physical. doi: 10.1113/EP09252: 1-13.
11. Hecht S, Rojas-Ruiz A, Boucher M, Henry C, Soliz J, Bossé Y. (2025). Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma. Lung. 29;203(1):84.: 1-7.
12. Sanchez L, Aliaga-Raduan F, Schneider-Gasser EM, Bairam A, Soliz J. Dysfunctional mitochondria as a novel mechanism to explain sleep apnea in adult mice exposed to neonatal stress. In process to be submited.
13. Vallejo A, Benavente J, Arias-Reyes C, Rojas-Ruiz A, Losantos K, Sanchez L, Soliz J. Brain mitochondrial bioenergetics remain unchanged in crickets colony reproduced for one year at 6% hypoxia. In submission.
14. Arias-Reyes C, Aliaga-Raduán F, Joseph V, and Soliz J. Mitochondrial plasticity in the retrosplenial cortex enhances mitochondrial bioenergetics during acclimatization to hypoxia in mice but not in rats. In submission.
15. Demarest M, Aliaga-Raduan F, Iturri P, Arias-Reyes C, Schneider-Gasser EM, Soliz J, Joseph V. Plasticity of mitochondrial proton leak in adults and newborn mice as a possible strategy for high altitude adaptation. In final preparation.
16. Aliaga-Raduán F, Demarest M, Rollano-Peñaloza O, Iturri P, Schneider-Gasser EM, Arias-Reyes C, Soliz J & Joseph V. Acclimatization to hypoxia triggers adaptive mitochondrial and cellular metabolic plasticity in the retrosplenial cortex of lab mice but not in rats. In final preparation.
17. Rojas-Ruiz A, Boucher M, Henry C, Packwood R, Soliz J, Bossé Y. Lung Volumes in a Mouse Model of Pulmonary Allergic Inflammation. Lung. 2024 Jul 17. doi: 10.1007/s00408-024-00730-1. Epub ahead of print. PMID: 39020115.
18. Gonzales M, Navia C, Tamayo C, Villarroel M, Jimenez-Aguilar R, Merino-Luna A, Sanchez L, Arias-Reyes C, Soliz J. Pneumonia is the leading cause of death from respiratory diseases at high altitude in Bolivia. 2024. IJIRMS. Volume09,Issue 02.
19. Jimenez-Aguilar R, Maravilla-Franco E, Carranza-Salazar D, Martinez Bautista J, Cantellano Orozco M, Tenorio Gutierrez W, Merino-Luna A, Albanez-Ayala C, Gonzales M, SanchezL, Arias-Reyes C, Duenas E, and Soliz J. Fly larvae induce urinary myiasis with no urinary symptoms but with neurological compromise. Medical Case Reports. August 28, 2023. Vol. 9 No 7:316.
20. Viruez-Soto A, Molano-Franco D, Tinoco-Solorzanoc A, Sanchez L, Arias-Reyes C, and Soliz J. Ultrasonic monitoring reveal lower baseline values of cardiac output, and tissue oxygen transport in high-altitude residents. Submitted.
21. Rojas-Ruiz A, Boucher M, Gill R, Gélinas L, Tom FQ, Fereydoonzad L, Graham P, Soliz J, Bossé Y. Lung stiffness of C57BL/6 versus BALB/c mice. Sci Rep 13, 17481 (2023).
22. Miard S, Lagüe E, Arias-Reyes C, Marcouiller F, Soliz J, Joseph V, Picard F. Loss of Malat1 mimics hypoxia-induced mitochondrial hypometabolism in brown adipose tissue by hindering PRDM16 traslation. En révision pour re-soumission
23. Arias-Reyes C, Joseph V, Soliz, J. divergent geographic distribution: mice, but not rats, are high altitude inhabitants. En révision pour re- soumission.
24. Aboouf MA, Thiersch M, Soliz J, Gassmann M, Schneider Gasser EM. The Brain at High Altitude: From Molecular Signaling to Cognitive Performance. Int J Mol Sci. 2023 Jun 15;24(12):10179.
25. Zubieta-DeUrioste N, Christian Arias-Reyes, Lida Sanchez, Nestor Freddy Armijo-Subieta, Alfredo Merino-Luna, Iván Solarte, Raffo Escalante-Kanashiro, José Antonio Carmona-Suazo, Enrique Maraví Poma, Rosalinda Jiménez-Aguilar, José M. Calle-Aracena, Alberto López Bascope, Roberto Vera, Rafaela Zubieta-DeUrioste, Ninoska Rossel, Yeshua Peña-Y-Lillo, Gary Chambi-Quilla, Luis Herrera-León, Santiago Garrido-Salazar, Francisco Ney Villacorta Cordova, Fausto Vinicio Maldonado Coronel, Elisabeth Deindl, Ricki Sheldon, Roberto Alfonso Accinelli, Edith. M. Schneider-Gasser, Soliz J#, Zubieta-Calleja G# . COVID-19 mortality is attenuated at high tropical and subtropical altitude: an observational study of a database covering five Latin American countries. International Journal of Molecular Science. Vol 11 No 8 (2023): August Issue, Vol.11, Issue 8.
26. Molano-Franco D, Viruez-Soto A, Gomez M, Beltran E, Villabon M, Sosa A, Ortiz L, Orozco E, Hurtado A, Sanchez L, Arias-Reyes C, Soliz J, and Masclans J. Impact Of The High-Flow Nasal Cannula Used In Patients With Covid-19 Ards At High Altitudes: Clinical Presentation and Prognostic for Mortality. Respiratory Care. Respir Care. 2023 Jun 13:respcare.10839.
27. Jimenez-Aguilar R, Merino-Luna A, Arias-Reyes C, Lozada Mata MP, Tenorio-Gutierrez W, Romero Martinez M, Duenas E, Viruez-Soto E, Molano-Franco D, Zubieta-Calleja G, Zubieta-DeUrioste N, Carmona Suazo JA, Tinoco-Solorzano A, Sanchez L, and Soliz J. Neutrophil/lymphocyte ratio (NLR) and lymphocyte/CRP ratio (LCR) are reliable predictors of adverse outcomes in high-altitude COVID-19 patients. European Journal of Clinical Investigation. Vol 11 No 8 (2023): August Issue, Vol.11, Issue 8 .
28. Sallé-Lefort S, Miard S, Henry C, Arias-Reyes C, Marcouiller F, Beaulieu MJ, Aubin S, Lechasseur A, Jubinville E, Marsolais D, Morissette M, Bossé Y, Joseph V, Soliz J, Maltais F, Bossé Y, Picard F. Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli. Front Physiol. 2022 Aug 29;13:949378.
29. Viruez-Soto A, Casas-Mamani R, Rada-Barrrera G, Merino-Luna A, Molano-Franco D, Tinoco-Solorzano A, Ambrosio-Marques D, Zubieta-DeUrioste N, Zubieta-Calleja G, Arias-Reyes C, Soliz J. Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudes. Respir Physiol Neurobiol. 2022 May; 299:103868.
30. Janes TA, Ambrozio-Marques D, Fournier S, Joseph V, Soliz J, Kinkead R.Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies. Front Physiol. 2022 Jul 8;13:964673.
31. Molano Franco D, Masclans Joan R, Nuvials X, Gomez M, Enciso C, Beltran E, Pérez M, Ramírez G, Gomez A, Escobar L, Arias-Reyes C, and Soliz, J. The Duration of Mechanical Ventilation is the Main Cause of Bacterial/Fungal Superinfection in Critically Ill Patients with COVID-19 at Altitude. 2022. Journal of Experimental Pathology. 3(2) :55-64.
32. Janes TA, Ambrozio-Marques D, Fournier S, Joseph V, Soliz J, and Kinkead R. Testosterone induces higher carotid body response to hypoxia in older adult male rats. Frontiers in Physiology. Front Physiol. 2021 Dec 24;12:781662.
33. Leon-Abarca JA, Portmann-Baracco A, Bryce-Alberti M, Ruiz-Sanchez C, Accinelli RA, Gonzales G, Soliz J. Diabetes increases the risk of COVID-19 in an altitude dependent manner: an analysis of 1,280,806 Mexican patients. PLOS ONE: 2021. 16:8.
34. Jacobs RA, Aboouf MA, Arias-Reyes C, Laouafa S, Koester-Hegmann C, Thiersch M, Gassmann M, Soliz J, Schneider Gasser EM. Erythropoietin overexpression in mice brain enhances postnatal hippocampal mitochondrial content, function and cognition. Communications Biology - Nature. 2021. 43(1) :938.
35. Viruez-Soto A, López-Dávalos MM, Rada-Barrera G, Merino-Luna A, Molano-Franco D, Tinoco-Solorzano A, Zubieta-DeUrioste N, Zubieta-Calleja G, Arias-Reyes C, Soliz J. Low serum erythropoietin levels are associated with fatal COVID-19 cases at 4,150 meters above sea level. Resp Physiol Neurobiol. 2021. 292: 103709.
36. Arias-Reyes C, Soliz, J, Joseph V. Rats and mice display different ventilatory, hematological, and metabolic features of acclimatization to hypoxia. Frontiers in Physiology. 2021. 12(2) : 647822.
37. Arias-Reyes C, Carvajal-Rodriguez F, Poma-Machicao L, Aliaga-Raduan F, Marques D, Zubieta DeUrioste N, Accinelli RA, Schneider-Gasser EM, Zubieta Calleja G, Dutschmann M, Soliz J. Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent. PLOS ONE. 2021. 16:3.
38. Elliot-Portal E, Arias-Reyes C, Tam R, Kinkead R, and Soliz J. (2021) Cerebral erythropoietin promotes sex dependent prevention of disrupted neural control of respiration induced by early life stress. Frontiers in Physiology. 2021. Dec 20;12:701344. doi: 10.3389/fphys.2021.701344. PMID: 34987412; PMCID: PMC8720854.
39. Arias-Reyes C, Laouafa S, Zubieta-DeUrioste N, Joseph V, Bairam A, Soliz J. Erythropoietin produces a dual effect on carotid body chemoreception in male rats. Front Pharmacol. 2021. Sep 14;12:727326.
40. Zubieta-DeUrioste N, Zubieta-Calleja G, Merino-Luna A, Armijo-Subieta NF, Soliz J, Arias-Reyes C, Escalante-Kanashiro R, Carmona-Suazo JA, López-Bascope,A, Calle-Aracena J, Epstein M & Maravi, Re: ‘‘Mor-tality Attributed to COVID-19 in High-Altitude Populations’’by Woolcott and Bergman. High Alt Med Biol 22:102–104. .